Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist

5-hydroxytryptamine (5-HT) is a key regulator of muscle contraction in parasitic flatworms. In Schistosoma mansoni, the myoexcitatory action of 5-HT is effected through activation of a serotonergic GPCR (Sm.5HTR(L)), prioritizing pharmacological characterization of this target for anthelmintic drug...

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Detaylı Bibliyografya
Yayımlandı:Int J Parasitol Drugs Drug Resist
Asıl Yazarlar: Chan, John D., Acharya, Sreemoyee, Day, Timothy A., Marchant, Jonathan S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2016
Konular:
Invited Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5196489/
https://ncbi.nlm.nih.gov/pubmed/27397763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2016.06.001
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