Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies

Complex cellular targets such as G protein-coupled receptors (GPCRs), ion channels, and other multi-transmembrane proteins represent a significant challenge for therapeutic antibody discovery, primarily because of poor stability of the target protein upon extraction from cell membranes. To assess wh...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Scott, Martin J., Jowett, Amanda, Orecchia, Martin, Ertl, Peter, Ouro-Gnao, Larissa, Ticehurst, Julia, Gower, David, Yates, John, Poulton, Katie, Harris, Carol, Mullin, Michael J., Smith, Kathrine J., Lewis, Alan P., Barton, Nick, Washburn, Michael L., de Wildt, Ruud
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188403/
https://ncbi.nlm.nih.gov/pubmed/32343620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1755069
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