Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2′-deoxyguanosine by the catalytic core of yeast DNA polymerase η

Reactive oxygen species damage DNA bases to produce 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG), which results in G:C to T:A transversions. To better understand mechanisms of dNTP incorporation opposite 8-oxoG, we performed pre-steady-state kinetic analysis of nucleotide incorporation using the cat...

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Gepubliceerd in:Biochimie
Hoofdauteurs: Xue, Qizhen, Zhong, Mengyu, Liu, Binyan, Tang, Yong, Wei, Zeliang, Guengerich, F. Peter, Zhang, Huidong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193378/
https://ncbi.nlm.nih.gov/pubmed/26700143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2015.12.009
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