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Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2′-deoxyguanosine by the catalytic core of yeast DNA polymerase η
Reactive oxygen species damage DNA bases to produce 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG), which results in G:C to T:A transversions. To better understand mechanisms of dNTP incorporation opposite 8-oxoG, we performed pre-steady-state kinetic analysis of nucleotide incorporation using the cat...
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| Publicado no: | Biochimie |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5193378/ https://ncbi.nlm.nih.gov/pubmed/26700143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2015.12.009 |
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