ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

Rho-associated kinase 2 (ROCK2) determines the balance between human T helper 17 (T(H)17) cells and regulatory T (T(reg)) cells. We investigated its role in the generation of T follicular helper (T(FH)) cellswhich provide help necessary to generate antibody-producing B cells in normal and autoimmune...

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Vydáno v:Sci Signal
Hlavní autoři: Weiss, Jonathan M., Chen, Wei, Nyuydzefe, Melanie S., Trzeciak, Alissa, Flynn, Ryan, Tonra, James R., Marusic, Suzana, Blazar, Bruce R., Waksal, Samuel D., Zanin-Zhorov, Alexandra
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193229/
https://ncbi.nlm.nih.gov/pubmed/27436361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad8953
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