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Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the resulting data can be integrated with a modeling and...
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| Publicado en: | J Pharmacol Exp Ther |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5193075/ https://ncbi.nlm.nih.gov/pubmed/27760784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.237495 |
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