Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the resulting data can be integrated with a modeling and...

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Bibliografiska uppgifter
I publikationen:J Pharmacol Exp Ther
Huvudupphovsmän: Tsamandouras, N., Kostrzewski, T., Stokes, C. L., Griffith, L. G., Hughes, D. J., Cirit, M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2017
Ämnen:
Metabolism, Transport, and Pharmacogenomics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193075/
https://ncbi.nlm.nih.gov/pubmed/27760784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.237495
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