Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the resulting data can be integrated with a modeling and...

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Tsamandouras, N., Kostrzewski, T., Stokes, C. L., Griffith, L. G., Hughes, D. J., Cirit, M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
Matèries:
Metabolism, Transport, and Pharmacogenomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193075/
https://ncbi.nlm.nih.gov/pubmed/27760784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.237495
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