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Integrated gut and liver microphysiological systems for quantitative in vitro pharmacokinetic studies

Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development and therefore several in vitro systems are routinely employed for this purpose. However, the need for more physiologically realistic in vitro models has recently fueled t...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Tsamandouras, Nikolaos, Chen, Wen Li Kelly, Edington, Collin D., Stokes, Cynthia L., Griffith, Linda G., Cirit, Murat
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540747/
https://ncbi.nlm.nih.gov/pubmed/28752430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-017-0122-4
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