Pharmacokinetic/Pharmacodynamic Modeling and Simulation of Cefiderocol, a Parenteral Siderophore Cephalosporin, for Dose Adjustment Based on Renal Function

Cefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent efficacy against most Gram-negative bacteria, including carbapenem-resistant strains. Since cefiderocol is excreted primarily via the kidneys, this study was conducted to develop a population pharmacokinetics (PK) model to de...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Katsube, Takayuki, Wajima, Toshihiro, Ishibashi, Toru, Arjona Ferreira, Juan Camilo, Echols, Roger
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192099/
https://ncbi.nlm.nih.gov/pubmed/27795374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01381-16
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