IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma

Accumulating evidences postulated the influential roles of macrophages in mediating hepatocellular carcinoma (HCC) initiation and progression. In this study, we demonstrate that a small molecule, genipin reduced HCC growth through suppressing IRE1α-mediated infiltration and priming of tumour associa...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Tan, Hor-Yue, Wang, Ning, Tsao, Sai-Wah, Che, Chi-Ming, Yuen, Man-Fung, Feng, Yibin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190060/
https://ncbi.nlm.nih.gov/pubmed/27270308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9696
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