Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF‐1α‐independent VEGF expression and angiogenesis in hepatocellular carcinoma

BACKGROUND AND PURPOSE: As a typical hypervascular tumour, hepatocellular carcinoma (HCC) is predominantly grown through angiogenesis. Geniposide is a promising anti‐inflammatory compound found in Gardenia jasminoides, but its effects on the progression of HCC remain untested. EXPERIMENTAL APPROACH:...

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Publicado en:Br J Pharmacol
Autores principales: Zhang, Cheng, Wang, Ning, Tan, Hor‐Yue, Guo, Wei, Chen, Feiyu, Zhong, Zhangfeng, Man, Kwan, Tsao, Sai Wah, Lao, Lixing, Feng, Yibin
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312435/
https://ncbi.nlm.nih.gov/pubmed/32144747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15046
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