Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

The androgen receptor (AR) plays a central role in prostate tumor growth. Inappropriate reactivation of the AR after androgen deprivation therapy promotes development of incurable castration-resistant prostate cancer (CRPC). In this study, we provide evidence that metabolic features of prostate canc...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Shah, Supriya, Carriveau, Whitney J., Li, Jinyang, Campbell, Sydney L., Kopinski, Piotr K., Lim, Hee-Woong, Daurio, Natalie, Trefely, Sophie, Won, Kyoung-Jae, Wallace, Douglas C., Koumenis, Constantinos, Mancuso, Anthony, Wellen, Kathryn E.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190055/
https://ncbi.nlm.nih.gov/pubmed/27248322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9666
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