Human HLA-A*02:01/CHM1(+) allo-restricted T cell receptor transgenic CD8(+) T Cells specifically inhibit Ewing sarcoma growth in vitro and in vivo

The endochondral bone protein Chondromodulin-I (CHM1) provides oncogene addiction in Ewing sarcoma (ES). We pre-clinically tested the targetability of CHM1 by TCR transgenic, allo-restricted, peptide specific T cells to treat ES. We previously generated allo-restricted wildtype CD8(+) T cells direct...

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Publicat a:Oncotarget
Autors principals: Blaeschke, Franziska, Thiel, Uwe, Kirschner, Andreas, Thiede, Melanie, Rubio, Rebeca Alba, Schirmer, David, Kirchner, Thomas, Richter, Gunther H.S., Mall, Sabine, Klar, Richard, Riddell, Stanley, Busch, Dirk H., Krackhardt, Angela, Grunewald, Thomas G.P., Burdach, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190022/
https://ncbi.nlm.nih.gov/pubmed/27281613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9218
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