Fluorescent probes reveal a minimal ligase recognition motif in the prokaryotic ubiquitin-like protein from Mycobac-terium tuberculosis

The prokaryotic ubiquitin-like protein (Pup) based proteasomal system in the pathogen Mycobacterium tuberculosis (Mtb) is essential for its survival in a mammalian host. The Pup ligase enzyme, PafA, conjugates Pup to a suite of proteins targeted for proteasomal degradation, and is necessary for pers...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Smirnov, Denis, Dhall, Abhinav, Sivanesam, Kalkena, Sharar, Rudy J., Chatterjee, Champak
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189686/
https://ncbi.nlm.nih.gov/pubmed/23402667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja311376h
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