Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium

The retinal pigment epithelium (RPE) is a monolayer of pigmented cells that requires an active metabolism to maintain outer retinal homeostasis and compensate for oxidative stress. Using (13)C metabolic flux analysis in human RPE cells, we found that RPE has an exceptionally high capacity for reduct...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Du, Jianhai, Yanagida, Aya, Knight, Kaitlen, Engel, Abbi L., Vo, Anh Huan, Jankowski, Connor, Sadilek, Martin, Tran, Van Thi Bao, Manson, Megan A., Ramakrishnan, Aravind, Hurley, James B., Chao, Jennifer R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187684/
https://ncbi.nlm.nih.gov/pubmed/27911769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604572113
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