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Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium

The retinal pigment epithelium (RPE) is a monolayer of pigmented cells that requires an active metabolism to maintain outer retinal homeostasis and compensate for oxidative stress. Using (13)C metabolic flux analysis in human RPE cells, we found that RPE has an exceptionally high capacity for reduct...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Du, Jianhai, Yanagida, Aya, Knight, Kaitlen, Engel, Abbi L., Vo, Anh Huan, Jankowski, Connor, Sadilek, Martin, Tran, Van Thi Bao, Manson, Megan A., Ramakrishnan, Aravind, Hurley, James B., Chao, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187684/
https://ncbi.nlm.nih.gov/pubmed/27911769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604572113
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