Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium

The retinal pigment epithelium (RPE) is a monolayer of pigmented cells that requires an active metabolism to maintain outer retinal homeostasis and compensate for oxidative stress. Using (13)C metabolic flux analysis in human RPE cells, we found that RPE has an exceptionally high capacity for reduct...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Du, Jianhai, Yanagida, Aya, Knight, Kaitlen, Engel, Abbi L., Vo, Anh Huan, Jankowski, Connor, Sadilek, Martin, Tran, Van Thi Bao, Manson, Megan A., Ramakrishnan, Aravind, Hurley, James B., Chao, Jennifer R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187684/
https://ncbi.nlm.nih.gov/pubmed/27911769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604572113
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