An NAD(+)-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

Accumulating evidence suggests cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD(+)). Nevertheless, how the regulation of this metabolic cofactor interfaces with signal transduction networks remains poorly understood in glioblastoma. Here, we...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gujar, Amit D., Le, Son, Mao, Diane D., Dadey, David Y. A., Turski, Alice, Sasaki, Yo, Aum, Diane, Luo, Jingqin, Dahiya, Sonika, Yuan, Liya, Rich, Keith M., Milbrandt, Jeffrey, Hallahan, Dennis E., Yano, Hiroko, Tran, David D., Kim, Albert H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187672/
https://ncbi.nlm.nih.gov/pubmed/27930300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610921114
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