The Fab Fragment of a Human Anti-Siglec-9 Monoclonal Antibody Suppresses LPS-Induced Inflammatory Responses in Human Macrophages

Sepsis is a major cause of death for hospitalized patients and is characterized by massive overreaction of immune responses to invading pathogens which is mediated by cytokines. For decades, there has been no effective treatment for sepsis. Sialic acid-binding, Ig-like lectin-9 (Siglec-9), is an imm...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Chu, Sasa, Zhu, Xuhui, You, Na, Zhang, Wei, Zheng, Feng, Cai, Binggang, Zhou, Tingting, Wang, Yiwen, Sun, Qiannan, Yang, Zhiguo, Zhang, Xin, Wang, Changjun, Nie, Shinan, Zhu, Jin, Wang, Maorong
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183739/
https://ncbi.nlm.nih.gov/pubmed/28082984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00649
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