Syrosingopine sensitizes cancer cells to killing by metformin

We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine’s known role as an inhibitor...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Adv
Κύριοι συγγραφείς: Benjamin, Don, Colombi, Marco, Hindupur, Sravanth K., Betz, Charles, Lane, Heidi A., El-Shemerly, Mahmoud Y. M., Lu, Min, Quagliata, Luca, Terracciano, Luigi, Moes, Suzette, Sharpe, Timothy, Wodnar-Filipowicz, Aleksandra, Moroni, Christoph, Hall, Michael N.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Association for the Advancement of Science 2016
Θέματα:
Research Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182053/
https://ncbi.nlm.nih.gov/pubmed/28028542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601756
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