AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway

The AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) modulates cellular energy metabolism, and promotes mitochondrial proliferation and apoptosis. Previous studies have shown that AICAR has anticancer effects in various cancers, however the roles of...

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Publicat a:Int J Oncol
Autors principals: Morishita, Masayuki, Kawamoto, Teruya, Hara, Hitomi, Onishi, Yasuo, Ueha, Takeshi, Minoda, Masaya, Katayama, Etsuko, Takemori, Toshiyuki, Fukase, Naomasa, Kurosaka, Masahiro, Kuroda, Ryosuke, Akisue, Toshihiro
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2016
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182012/
https://ncbi.nlm.nih.gov/pubmed/27878239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2016.3775
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