RNA-Seq of Huntington’s disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation

Innate immune activation beyond the central nervous system is emerging as a vital component of the pathogenesis of neurodegeneration. Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The systemic innate immune system is thought...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Miller, James R. C., Lo, Kitty K., Andre, Ralph, Hensman Moss, Davina J., Träger, Ulrike, Stone, Timothy C., Jones, Lesley, Holmans, Peter, Plagnol, Vincent, Tabrizi, Sarah J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181590/
https://ncbi.nlm.nih.gov/pubmed/27170315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw142
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