The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells

BACKGROUND: Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Cancer
Main Authors: Yedid, Nofar, Kalma, Yael, Malcov, Mira, Amit, Ami, Kariv, Revital, Caspi, Michal, Rosin-Arbesfeld, Rina, Ben-Yosef, Dalit
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180406/
https://ncbi.nlm.nih.gov/pubmed/28010732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2809-9
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