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The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells
BACKGROUND: Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads...
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| Publicado no: | BMC Cancer |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5180406/ https://ncbi.nlm.nih.gov/pubmed/28010732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2809-9 |
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