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The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin
Wnt/β-catenin signaling plays a central role in development and is also involved in a diverse array of diseases. β-Catenin activity is tightly regulated via a multiprotein complex that includes the kinase glycogen synthase kinase-3β (GSK-3β). GSK-3β phosphorylates β-catenin, marking it for ubiquitin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031469/ https://ncbi.nlm.nih.gov/pubmed/21118991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-05-0440 |
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