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A Novel Functional Screen in Human Cells Identifies MOCA as a Negative Regulator of Wnt Signaling
Aberrant Wnt signal transduction is involved in many human diseases such as cancer and neurodegenerative disorders. The key effector protein of the canonical Wnt pathway is β-catenin, which functions with T-cell factor/lymphoid enhancer factor (TCF/LEF) to activate gene transcription that leads to e...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575172/ https://ncbi.nlm.nih.gov/pubmed/18716063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-10-1046 |
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