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Canonical Wnt signaling negatively regulates platelet function

Wnts regulate important intracellular signaling events, and dysregulation of the Wnt pathway has been linked to human disease. Here, we uncover numerous Wnt canonical effectors in human platelets where Wnts, their receptors, and downstream signaling components have not been previously described. We...

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Detalhes bibliográficos
Main Authors: Steele, Brian M., Harper, Matthew T., Macaulay, Iain C., Morrell, Craig N., Perez-Tamayo, Alita, Foy, Martina, Habas, Raymond, Poole, Alastair W., Fitzgerald, Desmond J., Maguire, Patricia B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785253/
https://ncbi.nlm.nih.gov/pubmed/19901330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906268106
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