Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Hematopoietic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, congenital immunodeficiencies, and other conditions, possibly including AIDS. Autologous HSCT using genetically corrected cells would avoid the risk of graft-versus-host disease (GVHD), but t...

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Publicat a:Nat Biotechnol
Autors principals: Palchaudhuri, Rahul, Saez, Borja, Hoggatt, Jonathan, Schajnovitz, Amir, Sykes, David B, Tate, Tiffany A, Czechowicz, Agnieszka, Kfoury, Youmna, Ruchika, FNU, Rossi, Derrick J, Verdine, Gregory L, Mansour, Michael K, Scadden, David T
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179034/
https://ncbi.nlm.nih.gov/pubmed/27272386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3584
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