Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

Hematopoietic stem cell transplantation (HSCT) is a curative therapy for blood and immune diseases with potential for many settings beyond current standard-of-care. Broad HSCT application is currently precluded largely due to morbidity and mortality associated with genotoxic irradiation or chemother...

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Publicado no:Nat Commun
Main Authors: Czechowicz, Agnieszka, Palchaudhuri, Rahul, Scheck, Amelia, Hu, Yu, Hoggatt, Jonathan, Saez, Borja, Pang, Wendy W., Mansour, Michael K., Tate, Tiffany A., Chan, Yan Yi, Walck, Emily, Wernig, Gerlinde, Shizuru, Judith A., Winau, Florian, Scadden, David T., Rossi, Derrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365495/
https://ncbi.nlm.nih.gov/pubmed/30728354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08201-x
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