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Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration

One hallmark of Alzheimer´s disease are senile plaques consisting of amyloid beta (Aβ), which derives from the processing of the amyloid precursor protein (APP). Mitochondrial dysfunction has been linked to the pathogenesis of Alzheimer´s disease and both Aβ and APP have been reported to affect mito...

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Опубликовано в: :PLoS One
Главные авторы: Schaefer, Patrick M., von Einem, Bjoern, Walther, Paul, Calzia, Enrico, von Arnim, Christine A. F.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178995/
https://ncbi.nlm.nih.gov/pubmed/28005987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168157
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