The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

Proteolytic processing of amyloid-β precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) is the initial step in the production of amyloid beta (Aβ), which accumulates in senile plaques in Alzheimer’s disease (AD). Essential for this cleavage is the transport and sorting of both protein...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: von Einem, Bjoern, Wahler, Anke, Schips, Tobias, Serrano-Pozo, Alberto, Proepper, Christian, Boeckers, Tobias M., Rueck, Angelika, Wirth, Thomas, Hyman, Bradley T., Danzer, Karin M., Thal, Dietmar R., von Arnim, Christine A. F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460050/
https://ncbi.nlm.nih.gov/pubmed/26053850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129047
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