The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

Proteolytic processing of amyloid-β precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) is the initial step in the production of amyloid beta (Aβ), which accumulates in senile plaques in Alzheimer’s disease (AD). Essential for this cleavage is the transport and sorting of both protein...

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Bibliographic Details
Published in:PLoS One
Main Authors: von Einem, Bjoern, Wahler, Anke, Schips, Tobias, Serrano-Pozo, Alberto, Proepper, Christian, Boeckers, Tobias M., Rueck, Angelika, Wirth, Thomas, Hyman, Bradley T., Danzer, Karin M., Thal, Dietmar R., von Arnim, Christine A. F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460050/
https://ncbi.nlm.nih.gov/pubmed/26053850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129047
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