Mutational Analysis of the N-Terminal DNA-Binding Domain of Sleeping Beauty Transposase: Critical Residues for DNA Binding and Hyperactivity in Mammalian Cells

The N-terminal domain of the Sleeping Beauty (SB) transposase mediates transposon DNA binding, subunit multimerization, and nuclear translocation in vertebrate cells. For this report, we studied the relative contributions of 95 different residues within this multifunctional domain by large-scale mut...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yant, Stephen R., Park, Julie, Huang, Yong, Mikkelsen, Jacob Giehm, Kay, Mark A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2004
Pynciau:
DNA Dynamics and Chromosome Structure
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC517896/
https://ncbi.nlm.nih.gov/pubmed/15456893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.9239-9247.2004
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg