Mutational Analysis of the N-Terminal DNA-Binding Domain of Sleeping Beauty Transposase: Critical Residues for DNA Binding and Hyperactivity in Mammalian Cells

The N-terminal domain of the Sleeping Beauty (SB) transposase mediates transposon DNA binding, subunit multimerization, and nuclear translocation in vertebrate cells. For this report, we studied the relative contributions of 95 different residues within this multifunctional domain by large-scale mut...

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Detalhes bibliográficos
Main Authors: Yant, Stephen R., Park, Julie, Huang, Yong, Mikkelsen, Jacob Giehm, Kay, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517896/
https://ncbi.nlm.nih.gov/pubmed/15456893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.9239-9247.2004
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