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Mutational Analysis of the N-Terminal DNA-Binding Domain of Sleeping Beauty Transposase: Critical Residues for DNA Binding and Hyperactivity in Mammalian Cells

The N-terminal domain of the Sleeping Beauty (SB) transposase mediates transposon DNA binding, subunit multimerization, and nuclear translocation in vertebrate cells. For this report, we studied the relative contributions of 95 different residues within this multifunctional domain by large-scale mut...

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Bibliografske podrobnosti
Main Authors: Yant, Stephen R., Park, Julie, Huang, Yong, Mikkelsen, Jacob Giehm, Kay, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC517896/
https://ncbi.nlm.nih.gov/pubmed/15456893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.9239-9247.2004
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