Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.

Somatic mutation in immunoglobulin genes is localized to a 2-kilobase region of DNA surrounding and including rearranged variable (V), diversity, and joining (J) gene segments encoding heavy and light chains. To examine the structural basis for targeted mutation, we developed an assay to score mutat...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Umar, A, Schweitzer, P A, Levy, N S, Gearhart, J D, Gearhart, P J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1905016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.11.4902
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