Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.

Somatic mutation in immunoglobulin genes is localized to a 2-kilobase region of DNA surrounding and including rearranged variable (V), diversity, and joining (J) gene segments encoding heavy and light chains. To examine the structural basis for targeted mutation, we developed an assay to score mutat...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Umar, A, Schweitzer, P A, Levy, N S, Gearhart, J D, Gearhart, P J
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1991
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1905016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.11.4902
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