Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.

Somatic mutation in immunoglobulin genes is localized to a 2-kilobase region of DNA surrounding and including rearranged variable (V), diversity, and joining (J) gene segments encoding heavy and light chains. To examine the structural basis for targeted mutation, we developed an assay to score mutat...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Umar, A, Schweitzer, P A, Levy, N S, Gearhart, J D, Gearhart, P J
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1905016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.11.4902
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