Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity

Gene dosage toxicity (GDT) is an important factor that determines optimal levels of protein abundances, yet its molecular underpinnings remain unknown. Here, we demonstrate that overexpression of DHFR in E. coli causes a toxic metabolic imbalance triggered by interactions with several functionally r...

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Udgivet i:eLife
Main Authors: Bhattacharyya, Sanchari, Bershtein, Shimon, Yan, Jin, Argun, Tijda, Gilson, Amy I, Trauger, Sunia A, Shakhnovich, Eugene I
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176355/
https://ncbi.nlm.nih.gov/pubmed/27938662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20309
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