Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity

Gene dosage toxicity (GDT) is an important factor that determines optimal levels of protein abundances, yet its molecular underpinnings remain unknown. Here, we demonstrate that overexpression of DHFR in E. coli causes a toxic metabolic imbalance triggered by interactions with several functionally r...

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Vydáno v:eLife
Hlavní autoři: Bhattacharyya, Sanchari, Bershtein, Shimon, Yan, Jin, Argun, Tijda, Gilson, Amy I, Trauger, Sunia A, Shakhnovich, Eugene I
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176355/
https://ncbi.nlm.nih.gov/pubmed/27938662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20309
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