A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties

Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubility limit resulting in crystallization in joints, ac...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Nyborg, Andrew C., Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C., Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O’Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N., Wilson, David M., Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y., Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A., Osbourn, Jane, Coats, Steven, Baca, Manuel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176304/
https://ncbi.nlm.nih.gov/pubmed/28002433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167935
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