A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties

Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubility limit resulting in crystallization in joints, ac...

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Pubblicato in:PLoS One
Autori principali: Nyborg, Andrew C., Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C., Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O’Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N., Wilson, David M., Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y., Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A., Osbourn, Jane, Coats, Steven, Baca, Manuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176304/
https://ncbi.nlm.nih.gov/pubmed/28002433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167935
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