A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties

Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubility limit resulting in crystallization in joints, ac...

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Publicat a:PLoS One
Autors principals: Nyborg, Andrew C., Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C., Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O’Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N., Wilson, David M., Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y., Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A., Osbourn, Jane, Coats, Steven, Baca, Manuel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176304/
https://ncbi.nlm.nih.gov/pubmed/28002433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167935
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