Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

Phosphorylation of the p53 tumor suppressor at Ser20 (murine Ser23) has been proposed to be critical for disrupting p53 interaction with its negative regulator, MDM2, and allowing p53 stabilization. To determine the importance of Ser23 for the function of p53 in vivo, we generated a mouse in which t...

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Detalhes bibliográficos
Main Authors: MacPherson, David, Kim, Jungho, Kim, Teresa, Rhee, Byung Kirl, van Oostrom, Conny Th M, DiTullio, Richard A, Venere, Monica, Halazonetis, Thanos D, Bronson, Roderick, de Vries, Annemieke, Fleming, Mark, Jacks, Tyler
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517606/
https://ncbi.nlm.nih.gov/pubmed/15343266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600363
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