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Molecular insights into the mechanism of calmodulin inhibition of the EAG1 potassium channel

The human EAG1 potassium channel belongs to the superfamily of KCNH voltage-gated potassium channels that have roles in cardiac repolarization and neuronal excitability. EAG1 is strongly inhibited by Ca(2+)-calmodulin (CaM) through a mechanism that is not understood. We determined the binding proper...

詳細記述

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書誌詳細
出版年:Structure
主要な著者: Marques-Carvalho, Maria João, Oppermann, Johannes, Muñoz, Eva, Fernandes, Andreia S., Gabant, Guillaume, Cadene, Martine, Heinemann, Stefan H., Schönherr, Roland, Morais-Cabral, João Henrique
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176025/
https://ncbi.nlm.nih.gov/pubmed/27618660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.07.020
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