Molecular insights into the mechanism of calmodulin inhibition of the EAG1 potassium channel

The human EAG1 potassium channel belongs to the superfamily of KCNH voltage-gated potassium channels that have roles in cardiac repolarization and neuronal excitability. EAG1 is strongly inhibited by Ca(2+)-calmodulin (CaM) through a mechanism that is not understood. We determined the binding proper...

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Publicado no:Structure
Main Authors: Marques-Carvalho, Maria João, Oppermann, Johannes, Muñoz, Eva, Fernandes, Andreia S., Gabant, Guillaume, Cadene, Martine, Heinemann, Stefan H., Schönherr, Roland, Morais-Cabral, João Henrique
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176025/
https://ncbi.nlm.nih.gov/pubmed/27618660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.07.020
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