Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen

Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers the first example of an AEGIS aptamer that binds to an isolated protein target, the first whose structural contact with its target has bee...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Biondi, Elisa, Lane, Joshua D., Das, Debasis, Dasgupta, Saurja, Piccirilli, Joseph A., Hoshika, Shuichi, Bradley, Kevin M., Krantz, Bryan A., Benner, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175368/
https://ncbi.nlm.nih.gov/pubmed/27701076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw890
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