Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen

Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers the first example of an AEGIS aptamer that binds to an isolated protein target, the first whose structural contact with its target has bee...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Biondi, Elisa, Lane, Joshua D., Das, Debasis, Dasgupta, Saurja, Piccirilli, Joseph A., Hoshika, Shuichi, Bradley, Kevin M., Krantz, Bryan A., Benner, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175368/
https://ncbi.nlm.nih.gov/pubmed/27701076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw890
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