Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA

Chtop (chromatin target of Prmt1) regulates various aspects of gene expression including transcription and mRNA export. Despite these important functions, the regulatory mechanism underlying Chtop expression remains undetermined. Using Chtop-expressing human cell lines, we demonstrate that Chtop exp...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Izumikawa, Keiichi, Yoshikawa, Harunori, Ishikawa, Hideaki, Nobe, Yuko, Yamauchi, Yoshio, Philipsen, Sjaak, Simpson, Richard J, Isobe, Toshiaki, Takahashi, Nobuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175361/
https://ncbi.nlm.nih.gov/pubmed/27683223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw831
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