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β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase
The heterotrimeric AMP-activated protein kinase (AMPK), consisting of α, β and γ subunits, is a stress-sensing enzyme that is activated by phosphorylation of its activation loop in response to increases in cellular AMP. N-terminal myristoylation of the β-subunit has been shown to suppress Thr172 pho...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5175161/ https://ncbi.nlm.nih.gov/pubmed/28000716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39417 |
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