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Effect of various anticoagulants on the bioanalysis of drugs in rat blood: implication for pharmacokinetic studies of anticancer drugs

BACKGROUND: Pharmacokinetic studies are vital in development and optimization of drugs. While blood samples can be collected either in EDTA, heparin or citrate containing tubes for the estimation of drug levels in plasma, EDTA tubes are more commonly used. The purpose of this study was to evaluate t...

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Detalhes bibliográficos
Publicado no:Springerplus
Main Authors: Kulkarni, Preeti, Karanam, Ashwin, Gurjar, Murari, Dhoble, Sagar, Naik, Arvind B., Vidhun, Bhaskar H., Gota, Vikram
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5174014/
https://ncbi.nlm.nih.gov/pubmed/28053832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-016-3770-4
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