Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity

The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that regulates non-translational cellular functions. Here we found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following viral infection and exhibited potent antiviral activity. In...

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Publicado no:Nat Immunol
Main Authors: Lee, Eun-Young, Lee, Hyun-Cheol, Kim, Hyun-Kwan, Jang, Song Yee, Park, Seong-Jun, Kim, Yong-Hoon, Kim, Jong Hwan, Hwang, Jungwon, Kim, Jae-Hoon, Kim, Tae-Hwan, Arif, Abul, Kim, Seon-Young, Choi, Young-Ki, Lee, Cheolju, Lee, Chul-Ho, Jung, Jae U, Fox, Paul L, Kim, Sunghoon, Lee, Jong-Soo, Kim, Myung Hee
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173487/
https://ncbi.nlm.nih.gov/pubmed/27595231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3542
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