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Thymic dendritic cell subsets display distinct efficiencies and mechanisms of intercellular MHC transfer

Thymic dendritic cells (DC) delete self-Ag-specific thymocytes, and drive development of FoxP3-expressing immunoregulatory T cells. Unlike medullary thymic epithelial cells (mTEC), which express and present peripheral self-Ag, DC must acquire self-Ag to mediate thymic negative selection. One such me...

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Vydáno v:J Immunol
Hlavní autoři: Kroger, Charles J., Spidale, Nicholas A., Wang, Bo, Tisch, Roland
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173434/
https://ncbi.nlm.nih.gov/pubmed/27895179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601516
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