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Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα(+) DC function
Dysregulation of negative selection contributes to T cell-mediated autoimmunity, such as type 1 diabetes. The events regulating thymic negative selection, however, are ill-defined. Work by our group and others suggest that negative selection is inefficient early in ontogeny and increases with age. T...
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| Publicado no: | Eur J Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5138854/ https://ncbi.nlm.nih.gov/pubmed/27501268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201646354 |
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